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ea0070aep185 | Bone and Calcium | ECE2020

Calcium-sensing receptor gene polymorphisms and their effect on response to cinacalcet treatment in patients with secondary hyperparathyroidism in chronic kidney diseases

Egshatyan Lilit , Filippova Tamara , Nuralieva Sevda , Svetlichnaya Diana , Asanov Aliy , Litvinova Maria

Background: Secondary hyperparathyroidism (SHPT) is an adaptive process that develops in response to declining kidney function, impaired phosphate excretion, and failure to bioactivate vitamin D. The signal transduction via the calcium-sensing receptor (CaSR) is a key determinant of parathyroid gland hyperplasia.Aims: To examine the polymorphisms rs1801725 (p.Ala986Ser, G>T), rs1042636 (p.Arg990Gly, A>G), rs1801726 (p.Glu1021Gln, G>C) of ...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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